Vol. 12, Special Issue 10 (2023)

Author(s):
Sangeetha S Gireesh, Preena P, Chandrama Rabha and Reena Mukherjee

Abstract:
Methicillin-resistant Staphylococcus aureus (MRSA), an emerging pathogen in the livestock sector, is a severe challenge to bovine mastitis therapy due to its low susceptibility to commonly used antibiotics. There is an urgent need for alternate treatment modalities, where antimicrobial peptides like Lactoferrin are gaining importance. The prophylactic and therapeutic potential of Bovine recombinant Lactoferrin was studied in the murine mastitis model by intramammary introduction of MRSA into lactating mice. The efficacy of Lactoferrin was studied and evaluated through haematological changes, IL-17, IL-10 and IgG level estimation and acute phase reaction. The CRP qualitative reaction was positive in infected, untreated mice, while CRP was negative in treated mice. IgG production was increased in all infected animals. IL-17 concentration increased at day 3 and day 6 PC in infected, untreated mice, while in treated mice, there was an increase followed by a decrease. IL-10 concentration had increased, followed by a decrease in all infected animals.