Vol. 12, Special Issue 10 (2023)

Author(s):
Ranjith D, Mahantesh MT, Telang AG, Radha J, Sudharani R, Kavitha Ullikashi and Chethan T

Abstract:
The current study was carried out to understand ethion-induced hemotoxicity in male wistar albino rats, as well as the effect of Mangifera indica lead extract (MLE) and Quercetin alone and in combination given orally for 60 days. Following administration, ethion (7.2 mgkg^-1) caused a significant increase in granulocyte percentage, lymphocyte count, and WBC count, as well as a remarkable reduction in RBC count, hemoglobin, MCHC, MCH, and MCV levels, which was attributed for oxidative stress, reducing RBC lifespan and the drug's immune reaction in the body by ethion. The increase in RDW in ethion-treated rats was also observed as a result of chronic inflammation. Upon pre-administration of MLE (400 mgkg^-1) and quercetin (50 mgkg^-1) demonstrated a protective effect in the ethion-treated group, however the combination of both has shown an significant difference in normalizing the toxic effects.