Vol. 12, Special Issue 10 (2023)

Author(s):
C Yugandhar, RV Ramanamurty, K Sujatha, N Vinod Kumar, TNVKV Prasad and U Vinod

Abstract:
Monosodium Glutamate (MSG) is one of the world’s most extensively used food additive in human and livestock diets. Monosodium glutamate (MSG) is the sodium salt of amino acid glutamate, which is the main excitatory neurotransmitter in the body. The present study was carried out to evaluate the potential protective role of ZnO NPs against MSG induced oxidative stress in liver, kidney and testes of male wistar albino rats. For this experiment 48 male wistar albino rats weighing 130-170g Body Weight were procured and devided into 4 groups. Each group having 12 rats. Among four groups, Group I and group III served as negative control and zinc oxide nano particle (ZnO NPs) control respectively. Group II served as monosodium glutamate (MSG) toxic control, where MSG given orally at the dose rate of 5g/kg body weight daily and Group IV served as ZnO NPs ameliorated group where dose given daily (5g/kg b.wt of MSG + 10 mg/kg b.wt of ZnO NPs) for a period of six weeks. All the rats from each group were sacrificed randomly at 6th week after starting the experiment. The study revealed that MSG @ 5 g/ kg b.wt /day orally for 6 weeks was toxic to rats and caused induced adverse effects of oxidative stress changes in various visceral organs by increasing the production of lipid peroxidation and reactive oxygen species (ROS) due to decreased levels of antioxidants. The present study revealed reduced glutathione peroxidise (GPx), super oxide dismutase (SOD) and catalase in liver, kidney and testes were observed in MSG treated rats (Group II). ZnO nanoparticles significantly reduced oxidative damage in liver, kidney and testicular tissues to great extent in MSG induced rats.