Vol. 12, Special Issue 10 (2023)

Author(s):
Sneha Verma, Divya Gupta, Kanchan Awasthi and Ramakant

Abstract:
This review paper explores the complex interplay between diabetes mellitus, neuropathy, and cognitive impairment. It delves into the underlying mechanisms, clinical manifestations, shared risk factors, diagnostic tools, management approaches, an extremely troublesome consequence of diabetes mellitus is diabetic neuropathy. It is linked to extreme morbidity, death, and a significant financial cost. The anatomical complexity of the brain has rendered it susceptible to a range of pathological illnesses, including T₂DM, and it has been shown that high blood sugar affects important brain regions involved in learning, memory, and spatial navigation. According to studies, patients with diabetes might have a cognitive loss that may go unnoticed for years. Furthermore, research on brain imaging suggests that hyperglycemia or a condition that co-occurs with T₂D has broad impacts on several brain areas in people with T₂D. Although the precise mechanism causing diabetes-related cognitive impairment is unclear, aberrant insulin function and decreased glucose metabolism are considered to play significant roles.