Vol. 12, Special Issue 11 (2023)

Author(s):
BB Khutey, Raju Sharda, Rukmani Dewangan and Sumeet Pal

Abstract:
The present study was conducted to evaluate the physiological and haemodynamic alternations following thiopentone sodium anaesthesia premedicated with butorphanol, dexmedetomidine and acepromazine in dogs. Eighteen adult dogs of either sex were randomly divided into three groups (A, B and C) with six animals in each. Ten minutes prior to the anaesthetic administration, all the dogs were premedicated with glycopyrrolate @ 0.02 mg/kg I/M. The animals of group A, B and C were premedicated intramuscularly with butorphanol @ 0.3 mg/kg b.wt., dexmedetomidine @ 10 µg/kg b.wt. and acepromazine @ 0.4 mg/kg b.wt. respectively. General anaesthesia was induced with thiopentone sodium @ 18 mg/kg b.wt. Physiological and haemodynamic parameters viz. rectal temperature, heart rate, respiration rate, systolic, diastolic, mean blood pressure, SpO₂ and CRT were recorded before (0), 5 min. following sedation, after induction and at 10, 20, 40, 60 and 120 min. post thiopentone anaesthesia. The physiological and haemodynamic parameters displayed transient changes that were compensated and remained within normal range during the study period. Therefore, it can be concluded that thiopentone sodium can be administered safely as an induction agent in dogs premedicated with butorphanol or dexmedetomidine or acepromazine.