Vol. 12, Special Issue 11 (2023)

Author(s):
Navjot Singh Thakur, U Dimri, DB Mondal, Ensha Lomiya MA, Kavitha K and MR Verma

Abstract:
The vitamin D3's potential significance as an antioxidant has not received enough attention. It has mostly been examined for its impact on the metabolism of calcium and phosphorus. This investigation aims to clarify the vitamin D3's antioxidant capabilities. Apparently healthy dogs (n = 16) were selected and divided into two groups based on their age, Group I: < 8 years and Group II: 8 years & above. Since there were age-related alterations in the oxidant-antioxidant profile, vitamin D3 (cholecalciferol drops) was used to amelioration. The changes in oxidant-antioxidant profile were measured on the day 0, day 15th, and day 30th of therapy. The mean values of lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) were significantly (p<0.05) higher in group II as compared to group I whereas the mean values of reduced glutathione (GSH) was significantly (P<0.05) lower in group II compared to group I on day 0. On 15^th and 30^th day, the mean values of LPO, SOD, CAT and GPX showed significant decline (p<0.05), while the mean values of GSH was significantly (p<0.05) higher in both vitamin D3 treated groups. The changes were more significant in older age group. Based on the findings of this study, it is concluded that vitamin D3 is having antioxidant potential especially in geriatric dogs.