Vol. 12, Special Issue 12 (2023)

Author(s):
Binita Baruah, Sarojini Mahanta Tamuli, Shameem Ara Begum, Biswajit Dutta, Durlav Prasad Bora, Biswajyoti Borah, Chandana Choudhury Barua and Shantanu Tamuly

Abstract:
Acute iron overload in rats associated with hepatotoxicity, nephrotoxicity and neurotoxicity. Iron toxicity induced labored breathing, abnormal posture and hyperaemia of the ear in treated rats. Body weights were found to be significantly decreased in all the treated groups. Relative organs weights were found to be significantly increased in all the treated groups. There was significant alteration in different antioxidant parameters (MDA, CAT, SOD and GPx). Necropsy revealed various gross alterations in many organs viz. liver, kidneys, brain, lungs, and heart with varying intensity include necrosis and congestion in liver and kidney, mild congestion of brain and heart, emphysema and pneumonia in lungs. Histopathological examination of liver, kidney and brain revealed fatty degeneration of hepatocytes, haemorrhage, degeneration and necrosis of kidney tubules, glomerular fragmentation and loss, neuronophagia, gliosis and neuronal degeneration etc.