Vol. 12, Special Issue 12 (2023)

Author(s):
KM Himani, S Anbazhagan, Lakshmi Prakasan, Dengam Geyi, Lulu Gonmei, Pallab Chaudhuri, Prasad Thomas, Akhilesh Kumar and K Narayanan

Abstract:
Double emulsions are liquid dispersion systems known also as emulsions of emulsion. Attractive interest on double emulsions comes from their unique morphology enabling them to act as multifunctional carriers. Double emulsions can encapsulate both hydrophilic and lipophilic molecules in the same particle. The aim of the study was to synthesize solid lipid nanoparticles (SLNs) applicable as drug delivery systems using stearic acid as the lipid source. The study further aimed characterize the de novo synthesized SLNs by DLS, SEM, FTIR and DSC for understanding their critical biophysical characteristics. Based on these analysis, the estimated mean size, PDI and charge of NPs were computed as 404.6 nm, 0.297 and + 28.4 mV, respectively. FTIR analysis indicate no change in the chemical structure of stearic acid in SLN. DSC analysis showed a decrease in the melting point from that of pure stearic acid. The study thus established standard procedures for laboratory synthesis of solid lipid nanoparticles followed by their biophysical characterization to prove their adequacy as multifunctional carriers including drugs.