Vol. 10, Special Issue 5 (2021)

Author(s):
MK Patil, AP Somkuwar and PV Patil

Abstract:
Experiment was performed on six healthy Marathwadi buffalo calves of either sex to study the different pharmacokinetic parameters after single intramuscular administration @ 2 mg/kg body weight by microbiological assay technique. Absorption half-life, distribution half-life, elimination half-life, volume of distribution, total body clearance, AUC, AUMC, MRT and bioavailability values found were 0.24 ± 0.02 h, 0.30 ± 0.03 h, 2.54 ± 0.12 h, 1.85 ± 0.17L/kg (Vd (B)) and 1.95 ± 0.19 L/kg (Vdss), 0.52 ± 0.04 L/kg.h^-1, 3.99 ±0.35 µg/ml.hr, 14.93 ±1.48 µg/ml.hr², 3.75± 0.18 h and 165.38% respectively. It may be concluded that the elimination half-life of cefquinome was 2.54 h in buffalo calves indicating the repeating of doses at 12 to 15 h intervals in buffalo calves. The loading dose would be double than the maintenance dose of cefquinome after intramuscular administration.