Vol. 10, Special Issue 9 (2021)

Author(s):
Dr. Veldi Pavani, Dr. M Lakshman, Dr. D Madhuri and Dr. A Gopala Reddy

Abstract:
The experiment was designed to study the pathology of lead acetate, tetramethylthiuram disulfide and its combination induced toxic effects in broilers. Hundred day old broiler chicks divided into four groups, 25chicks in each group. The group 1 (control) fed with basal diet, group 2 (lead acetate) at the rate of 300 ppm per day, group 3 (tetramethylthiuram disulfide) at the rate of 60 ppm per day and group 4 birds were fed with combination of lead acetate and tetramethylthiuram disulfide with same dose. The duration of experiment for 5 weeks and the age of the birds were 6 weeks (first week for acclimatization). Histopathological changes in liver and kidney were recorded at end of the 1^st, 3^rd and 5^th week of experiment. Histopathologically, alteration in liver and kidneys were severe on 5^th week of experiment. Liver showed congestion, necrosis, and cirrhosis. Kidney sections revealed vacuolar degeneration, haemorrhages and necrosis. The lesions were pronounced in group 4 comparatively group 2 and 3.