Vol. 10, Special Issue 11 (2021)

Author(s):
Sunil Punia, Tarun Kumar, Divya Agnihotri and Maneesh Sharma

Abstract:
Filgrastim is a recombinant Methionyl Human Granulocyte Colony-Stimulating Factor (r-metHuG-CSF) analog used to stimulate the proliferation and differentiation of granulocytes in humans. Young pups suffer from hemmoragic gastroenteritis (etiology may be viral like Canine Parvovirus or Canine Distemper Virus, bacterial like E.coli or parasitic) mainly associated with severe leukopenia and neutropenia. Neurtrophils being first line of defense against sepsis, decreased count may lead to increased mortality. In the present investigation eleven dogs with severe leukopenia and neutropenia when treated with Filgrastim @ 10 μg/ kg b.wt. s.c daily for three days along with other supportive treatment, was found to be effective in correcting the hematological picture within 48 hours of last dose of treatment and all the dogs showed fast recovery uneventfully.