Vol. 10, Special Issue 11 (2021)

Author(s):
Anu Malik, Sangeeta Das and Akhil Kumar Gupta

Abstract:
Sepsis remains the life threatening clinical condition with medical and economy burden healthcare units and hospitals globally. Despite of all clinical efforts and medical techniques, treatment and management of sepsis remains limited over the past three decades. With advances in understanding the evolution and pathophysiology of sepsis, it has been found that occurrence of sepsis cannot be attributed to pathogen only, but also alterations in immune response play a significant role in generation of sepsis. Treatment of sepsis involved early identification of patients at risk with prompt diagnosis and administration of appropriate antibiotics with all-purpose supportive care. This approach contributed to improved prognosis in management of sepsis and reducing the overall mortality rate. With the ongoing research and advances in clinical medicine, it has been investigated that more ameliorate measures have yet to yield better results. This review is aimed to provide outline about the immune pathophysiology and the progress made in the development of targeted therapy for management of sepsis over the decades with focus on more promising avenues for future research.