Vol. 10, Special Issue 12 (2021)

Author(s):
Borthakur A, Ramesh S, Gokulakannan R, Srinivasan MR, Kalaiselvi L and Ramasamy T

Abstract:
The present study has been undertaken to evaluate the various pharmacokinetic parameters of tilmicosin in broiler chicken at the dose rate of 1 kg/tonne of feed through in feed route. Eight birds were used in the study. Tilmicosin was administered by mixing with feed at the recommended dose of 1 g/Kg of feed. Blood samples were collected at different time intervals to separate the plasma and subsequent determination of plasma concentration of tilmicosin. Plasma concentration of tilmicosin was assayed using a validated sensitive HPLC method. Based on time vs concentration curve, various pharmacokinetic parameters were calculated. The desired MIC value of 0.1 µg/ml was maintained up to 12 hours. The results revealed an AUC of 21.51 µg.h².ml^-1, half-life of 21.45 h, MRT of 5.74 h. There was significant variability in pk parameters within the 8 birds subjected to trial, among which only 6 birds showed any plausible PK behaviour. It can be concluded that tilmicosin can be given mixed with feed to mainatain therapeutically relevant concentrations.